I think it's possible within fifty years or less, depending on politics and spenditure. The technology is already well enough that it's consistently possible to send humans into space.
A larger complex than simply a small research base would be my goal, something capable of at least a population of one hundred and fifty to circumvent problems with inbreeding should the need arise.
Something such as the
Lifeboat Foundation is trying to accomplish, the same people who tried and failed to create
Oceania(The Atlantis Project) a man-made continent.
If they had more legitimate support, such as the government and NASA it would leave the realm of crackpots. Some of the technology that foundation intends to use is pushing the envelope of feasibility. More low-tech solutions should be explored, while bio shields, etc are nice on paper implementation and development would take years.
Current technology should be pushed to it's limits, and effort made to go within the fifty year time frame.